TRANSLATIONAL PHYSIOLOGY Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts
نویسندگان
چکیده
Norishige Morita,* Jong-Hwan Lee,* Aneesh Bapat, Michael C. Fishbein, William J. Mandel, Peng-Sheng Chen, James N. Weiss, and Hrayr S. Karagueuzian Department of Medicine, Translational Arrhythmia Research Section, University of California Los Angeles Cardiovascular Research Laboratory and the Division of Cardiology, Los Angeles; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California; Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Electrocardiographic Heartbeat Organization, Los Angeles, California; and the Division of Cardiology, Krannert Institute, Indiana University, Bloomington, Indiana
منابع مشابه
Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts.
Selective glycolytic inhibition (GI) promotes electromechanical alternans and triggered beats in isolated cardiac myocytes. We sought to determine whether GI promotes triggered activity by early afterdepolarization (EAD) or delayed afterdepolarizations in intact hearts isolated from adult and aged rats. Dual voltage and intracellular calcium ion (Ca(i)(2+)) fluorescent optical maps and single c...
متن کاملSpontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition.
Aging and glycolytic inhibition (GI) are known to alter intracellular calcium ion (Ca(i)(2+)) handling in cardiac myocytes, causing early afterpotentials (EADs) and delayed afterpotentials. We hypothesized that aging and GI interact synergistically in intact hearts to generate EADs and triggered activity leading to atrial fibrillation (AF). We studied isolated and Langendorff-perfused hearts of...
متن کاملIncreased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.
Oxidative stress with hydrogen peroxide (H(2)O(2)) readily promotes early afterdepolarizations (EADs) and triggered activity (TA) in isolated rat and rabbit ventricular myocytes. Here we examined the effects of H(2)O(2) on arrhythmias in intact Langendorff rat and rabbit hearts using dual-membrane voltage and intracellular calcium optical mapping and glass microelectrode recordings. Young adult...
متن کاملProlonged Oral Administration of Oleuropein Might Protect Heart against Aconitine-induced Arrhythmia
In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...
متن کاملChemical ablation of the Purkinje system causes early termination and activation rate slowing of long-duration ventricular fibrillation in dogs.
Endocardial mapping has suggested that Purkinje fibers may play a role in the maintenance of long-duration ventricular fibrillation (LDVF). To determine the influence of Purkinje fibers on LDVF, we chemically ablated the Purkinje system with Lugol solution and recorded endocardial and transmural activation during LDVF. Dog hearts were isolated and perfused, and the ventricular endocardium was e...
متن کامل